Osteogenic cells

Osteogenic cells are stem-like progenitor cells found in the inner layer of the periosteum and endosteum, the tissues that line the outer and inner surfaces of bones. As the precursors to osteoblasts, these cells play a critical role in bone development, growth, and repair. When activated by injury, mechanical stress, or molecular signals, osteogenic cells differentiate into osteoblasts that produce bone matrix and promote mineralization. They also contribute to skeletal remodeling throughout life, helping maintain bone strength and structure. Their ability to self-renew and respond to environmental cues makes them central to regenerative medicine, particularly in treatments for osteoporosis, fractures, and skeletal disorders. Without properly functioning osteogenic cells, bone formation is impaired, leading to weakened or brittle bones.